Abstract
Several derivatives of cycloserine (1) were prepared and it was found that (R)-4-[(1-methyl-3-oxo-1-butenyl)-amino]-3-isoxazolidinone (11), the condensation product of acetylacetone and cycloserine (1), was an efficacious prodrug of increased stability under aqueous conditions.
MeSH terms
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Animals
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Cycloserine / analogs & derivatives*
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Cycloserine / chemical synthesis
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Cycloserine / pharmacology
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Cycloserine / urine
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Drug Stability
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Escherichia coli / drug effects
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Female
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Ketones*
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Mice
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Pentanones*
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Staphylococcus aureus / drug effects
Substances
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Ketones
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Pentanones
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acetylacetone
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Cycloserine