Abstract
Levels of penicillin both in blood and CSF are determined in 11 children with meningococcal meningitis. Authors compare these values with MIC. The therapeutic pattern was 500.000 Ul/Kg/day of benzylpenicillin, in six doses, with a single initial doses of 200.000 Ul/Kg. The results recommend not to use a lower doses in order to assure a permanently efficient penicillin concentration.
MeSH terms
-
Cerebrospinal Fluid Proteins / analysis
-
Child, Preschool
-
Female
-
Humans
-
Infant
-
Male
-
Meningitis, Meningococcal / blood
-
Meningitis, Meningococcal / cerebrospinal fluid
-
Meningitis, Meningococcal / drug therapy*
-
Penicillin G / administration & dosage
-
Penicillin G / analysis
-
Penicillin G / therapeutic use*
-
Time Factors
Substances
-
Cerebrospinal Fluid Proteins
-
Penicillin G