Abstract
Anti-acetylcholine-receptor antibody is demonstrable in more than 90 per cent of patients with myasthenia gravis. Serum antibody titers do not show a direct correlation with disease severity, although in certain patients antibody levels increase in association with disease activity. Impairment of neuromuscular transmission results from the loss of junctional receptors, either as a result of receptor internalization or destruction of junctional folds containing the acetylcholine receptor. Myasthenia gravis manifests immunologic, genetic, and clinical similarities to rheumatic syndromes, suggesting a generic immune dysfunction common to these disorders.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acetylcholine / metabolism
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Antibodies, Monoclonal / immunology
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Autoantibodies / immunology
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Autoimmune Diseases / immunology*
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Binding, Competitive
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Cholinesterase Inhibitors / therapeutic use
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Complement C3 / immunology
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Complement C9 / immunology
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Female
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Humans
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Immunization, Passive
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Immunosuppressive Agents / therapeutic use
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Male
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Membrane Proteins / immunology
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Myasthenia Gravis / drug therapy
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Myasthenia Gravis / immunology*
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Plasmapheresis
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Receptors, Cholinergic / immunology
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Snake Venoms / metabolism
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Synaptic Membranes / ultrastructure
Substances
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Antibodies, Monoclonal
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Autoantibodies
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Cholinesterase Inhibitors
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Complement C3
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Complement C9
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Immunosuppressive Agents
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Membrane Proteins
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Receptors, Cholinergic
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Snake Venoms
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Acetylcholine