Comparative studies on spontaneous and mitomycin-C-induced sister-chromatid exchanges in smokers and non-smokers

Mutat Res. 1982 Sep;105(3):195-200. doi: 10.1016/0165-7992(82)90011-2.

Abstract

Both spontaneous and mitomycin-C-induced sister-chromatid exchanges were analyzed in 6 smokers and 6 non-smokers. The average number of spontaneous SCE in smokers' cells was 8.33 +/- 1.08. The frequency in the non-smoking controls was 4.41 +/- 0.72. This difference is highly significant (P less than 0.001). Smokers also had more SCE at all levels of mitomycin C testes. Analysis of variance showed these differences to be highly significant (P less than 0.001).

Publication types

  • Comparative Study

MeSH terms

  • Cells, Cultured
  • Crossing Over, Genetic* / drug effects
  • Humans
  • Lymphocytes / drug effects
  • Male
  • Middle Aged
  • Mitomycin
  • Mitomycins / pharmacology*
  • Sister Chromatid Exchange* / drug effects
  • Smoking*

Substances

  • Mitomycins
  • Mitomycin