An acquired circulating inhibitor to Factor VIII:C was found in a 27-year-old postpartum woman who presented with ecchymoses and hematomas. Postpartum Factor VIII:C inhibitors can clinically manifest with signs and symptoms not unlike those in a classic hemophiliac. The natural history of this inhibitor is typically one of spontaneous disappearance with the return of the patient's previous hemostatic capacity. The authors describe a patient with the postpartum Factor VIII:C inhibitor, and discuss this unusual disease entity along with the therapeutic considerations.