Abstract
The synthesis of a series of dialkylaminoalkylic esters of 1-chloro-3-carboxy-4-methylisoquinoline and of 1-chloro-3-carboxy-4-phenylisoquinoline is described. The pharmacological activity of some of these compounds was studied. The morpholinoethylester of 1-chloro-3-carboxy-4-methylisoquinoline (VIIa), dimethylaminoethylester (VIIb) and diethylaminoethylester (VIIc) showed a good antispasmodic activity. 4-Phenyl-derivatives (XVa), (XVb), (XVc) were more active than analogous 4-methyl derivatives; particularly the diethylaminoethylester of 1-chloro-3-carboxy-4-phenylisoquinoline (XVc) showed an antagonist effect against spasmogens similar to that of papaverine.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylcholine / antagonists & inhibitors
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Analgesics / chemical synthesis
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Animals
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Anti-Inflammatory Agents / chemical synthesis
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Barium / antagonists & inhibitors
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Central Nervous System / drug effects
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Chemical Phenomena
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Chemistry
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Guinea Pigs
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Histamine Antagonists / chemical synthesis
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In Vitro Techniques
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Isoquinolines / chemical synthesis*
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Isoquinolines / pharmacology
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Male
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Mice
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Motor Activity / drug effects
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Parasympatholytics / chemical synthesis*
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Rats
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Rats, Inbred Strains
Substances
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Analgesics
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Anti-Inflammatory Agents
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Histamine Antagonists
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Isoquinolines
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Parasympatholytics
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Barium
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Acetylcholine