A neuropsychological evaluation of 41 patients with multiple sclerosis was carried out. The investigation included language and memory tests, a visual reproduction task, and one test sensitive to frontal lobe damage. The results show that most of the patients have neuropsychological defects mainly concerning memory. However, only one case of global deterioration was found. The result also suggest that men are more impaired than women, without correlation with age or length of illness. These findings are discussed in the light of the literature.