[The activity of microsomal hepatic cytochromes as affected by x-ray contrast media]

Farmakol Toksikol. 1978 Jun-Aug;41(4):450-4.
[Article in Russian]

Abstract

Tests on rats evidenced that X-ray contrast media can bring down the cytochrome P-450 content in the endoplasmatic reticulum of hepatic cells. The observed effect is most characteristic of cholecystrographic substances and is not linked with intesified processes of lipids peroxidation in themicrosomal membranes.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Cholecystography
  • Contrast Media / pharmacology*
  • Cytochrome P-450 Enzyme System / metabolism*
  • Endoplasmic Reticulum / drug effects
  • Endoplasmic Reticulum / enzymology
  • In Vitro Techniques
  • Microsomes, Liver / drug effects*
  • Microsomes, Liver / enzymology
  • Rats

Substances

  • Contrast Media
  • Cytochrome P-450 Enzyme System