Chromosome aberrations in human lymphocytes induced by fission neutrons

Int J Radiat Biol Relat Stud Phys Chem Med. 1984 May;45(5):449-57. doi: 10.1080/09553008414550651.

Abstract

The dose-response relationships of dicentrics and excess acentrics were analysed after exposure of human lymphocytes to a mixed fission neutron-gamma-ray beam. From the analysis of exclusively first division cells a linear-quadratic relation was obtained for dicentrics with the ratio of linear and quadratic components, zeta, equal to 2.76 Gy. Over the range of doses studied (0.04-1.97 Gy) intratrack events therefore predominated. This also applied to acentrics which were linearly related to dose. At the lowest level of observed effect and dose, r.b.e. values with respect to 60Co gamma-rays of up to about 11 were derived for dicentrics and acentrics. With increasing neutron dose the r.b.e. decreased.

Publication types

  • Comparative Study

MeSH terms

  • Chromosome Aberrations*
  • Cobalt Radioisotopes
  • Dose-Response Relationship, Radiation
  • Gamma Rays
  • Humans
  • Lymphocytes / radiation effects*
  • Neutrons*
  • Relative Biological Effectiveness

Substances

  • Cobalt Radioisotopes