[Acceleration of the synthesis of cardiac adenine nucleotides from adenosine as affected by propranolol]

Abstract

DL-propranolol, at a dose of 2 mg . l-1, induced in the isolated rat heart an increase in adenine nucleotide synthesis from exogenous 5 microM adenosine (+20%). If supplied during reperfusion following low-flow ischaemia (0.5 ml . min-1, 30 min.), propranolol annulled the decrease in adenosine incorporation (-23%) provoked by ischaemia. When propranolol was given during ischaemia and reperfusion, ATP degradation during the ischaemic period was reduced and adenosine uptake was strongly stimulated on reperfusion (+60%).