A patient with renal transplant developed muco-cutaneous Kaposi's sarcoma. The tumors appeared within a mont after surgery, while receiving daily 240 mgr . of methylprednisone and 150 mgr . of azathioprine. She received superficial radiotherapy ( Cesio 137) on her cutaneous lesions and the nasal tumor was removed with Laser radiation CO2 obtaining a favorable a response. Possible etiopathogenic mechanisms are mentioned. Clinical, epidemiologic, therapeutic and prognosis features of these transplanted subjects are discussed. Publications of other similar cases are reviewed.