In vitro production of azide mutagenic metabolite in Arabidopsis, Drosophila and Neurospora

Mutat Res. 1983 Mar;119(3):281-5. doi: 10.1016/0165-7992(83)90173-2.

Abstract

The ability of Arabidopsis, Drosophila and Neurospora to convert azide to its mutagenic metabolite was investigated. Cultures of these organisms all contained significant levels of O-acetylserine sulfhydrylase activity. Extracts from each organism produced a product from O-acetylserine and azide in vitro which was mutagenic in Salmonella typhimurium TA1530.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Azides / metabolism*
  • Brassica / metabolism*
  • Cysteine Synthase / metabolism
  • Drosophila / metabolism*
  • Mutagens / metabolism*
  • Neurospora / metabolism*
  • Salmonella typhimurium / drug effects*
  • Salmonella typhimurium / enzymology

Substances

  • Azides
  • Mutagens
  • Cysteine Synthase