Abstract
It was shown that irradiation of mice with the dose of 4 Gy affected the immune and haemopoietic systems. Diucyphone injected on days 6-8 after irradiation favoured the production of antibodies in the spleen, increased the yield of exogenous splenic colonies and corrected differentiation of the haemopoietic stem cells. In the normal body, diucyphone decreased the colony-forming activity and did not change the haemopoietic stem cell differentiation.
MeSH terms
-
Adjuvants, Immunologic*
-
Animals
-
Colony-Forming Units Assay
-
Drug Combinations / pharmacology
-
Hematopoietic Stem Cells / drug effects*
-
Hematopoietic Stem Cells / pathology
-
Immunity, Cellular / drug effects
-
Immunity, Cellular / radiation effects
-
Male
-
Mice
-
Radiation Injuries, Experimental / immunology*
-
Radiation Injuries, Experimental / pathology
-
Sulfones / pharmacology*
-
T-Lymphocytes / immunology
-
Uracil / analogs & derivatives*
-
Uracil / pharmacology
Substances
-
Adjuvants, Immunologic
-
Drug Combinations
-
Sulfones
-
diucifon
-
Uracil