Abstract
Promoter function in yeast has been examined by obtaining revertants of a his3 promoter deletion in vivo. Events which provide a new promoter for the his3 gene include insertion of the transposable element Ty1, rearrangements of the plasmid vector, and chromosomal mutations. A role for dicentric chromosomes as a source of the plasmid rearrangements is discussed.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Base Sequence
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Chromosome Deletion
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DNA Transposable Elements
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DNA, Fungal / genetics
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DNA, Recombinant
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Genes
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Mutation
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Operon*
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Plasmids
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Recombination, Genetic
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Repetitive Sequences, Nucleic Acid
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Yeasts / genetics*
Substances
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DNA Transposable Elements
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DNA, Fungal
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DNA, Recombinant