Twenty patients with inoperable squamous cell carcinoma of the lung (14 previously untreated and 6 previously treated) received a combination of bleomycin and cis-platinum for 6 consecutive days every 3 or 4 weeks. Pulmonary toxicity was minimal with only one case of reversible bleomycin-induced acute interstitial pneumopathy. The response rate was 65 p.cent. Thirteen patients had an objective response, including 5 apparently complete regressions. All responders were previously untreated patients. The results are discussed in the light of pharmacokinetic and cell kinetic data, and lead to a proposal for a non-conventional combined approach in squamous cell carcinoma of the lung, hitherto relatively unresponsive to chemotherapy.