Abstract
The molecular basis for the antiviral activity is discussed for a variety of nucleoside compounds approved for clinical use in the U.S.A. (5-iodo-2'-deoxyuridine, 5-trifluoromethyl-2'-deoxyuridine, 9-beta-D-arabinofuranosyladenine, 9-(2-hydroxyethoxymethyl)guanine), or in clinical trial (E-5-(2-bromovinyl)-2'-deoxyuridine, 1-(2-deoxy-2-fluoro-beta-D-arabinosyl)-5-iodocytosine, 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide), or of specific interest to our laboratory (5-iodo-5'-amino-2',5'-dideoxyuridine, 5'-amino-5'-deoxythymidine). The consequence of incorporation of idoxuridine, the 5'-amino analog of thymidine or the 5'-amino analog of idoxuridine into the DNA of herpes simplex virus type 1 on transcription and translation is emphasized.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Acyclovir / pharmacology
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Antiviral Agents / metabolism*
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Antiviral Agents / pharmacology
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Bromodeoxyuridine / analogs & derivatives
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Bromodeoxyuridine / pharmacology
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Cytarabine / analogs & derivatives
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Cytarabine / pharmacology
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DNA, Viral / genetics
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DNA, Viral / metabolism*
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Dideoxynucleosides*
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Idoxuridine / analogs & derivatives
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Idoxuridine / metabolism
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Idoxuridine / pharmacology
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Protein Biosynthesis / drug effects
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Ribavirin / pharmacology
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Simplexvirus / drug effects
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Structure-Activity Relationship
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Thymidine / analogs & derivatives
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Thymidine / metabolism
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Thymidine / pharmacology
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Thymine Nucleotides / administration & dosage
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Thymine Nucleotides / metabolism
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Transcription, Genetic / drug effects
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Vidarabine / metabolism
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Vidarabine / pharmacology
Substances
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Antiviral Agents
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DNA, Viral
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Dideoxynucleosides
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Thymine Nucleotides
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Cytarabine
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5'-amino-5'-deoxythymidine
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brivudine
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5-trifluoromethyl-2'-deoxyuridine 5'-triphosphate
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fiacitabine
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Ribavirin
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5'-amino-5-iodo-2',5'-dideoxyuridine
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Vidarabine
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Bromodeoxyuridine
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Idoxuridine
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Thymidine
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Acyclovir