Abstract
Dopamine hyperpolarizes growth hormone-producing cells (GHC) in the CNS of Lymnaea stagnalis. This effect of dopamine was mimicked by the D-2 receptor agonist LY 141865 and antagonized by the D-2 receptor antagonists (-)-sulpiride and YM 09151-2. SKF 38393, a selective D-1 receptor agonist, increased the excitability of the GHC. This effect was mimicked by intracellular injection of cyclic AMP and antagonized by the D-1 receptor antagonist SCH 23390. Dopamine (in the presence of (-)-sulpiride) also increased the excitability of the GHC. It is concluded that both a D-1 and a D-2 receptor regulate the electrical activity of the GHC in the CNS of Lymnaea stagnalis.
MeSH terms
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Animals
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Bucladesine / pharmacology
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Central Nervous System / metabolism
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Cyclic AMP / pharmacology
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Dopamine / pharmacology
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Electrophysiology
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Ergolines / pharmacology
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Growth Substances / biosynthesis*
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In Vitro Techniques
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Invertebrate Hormones / biosynthesis*
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Lymnaea / physiology*
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Membrane Potentials / drug effects
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Microelectrodes
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Quinpirole
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Receptors, Dopamine / physiology*
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Receptors, Dopamine D1
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Receptors, Dopamine D2
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Sulpiride / pharmacology
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Tetrahydronaphthalenes / pharmacology
Substances
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Ergolines
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Growth Substances
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Invertebrate Hormones
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Receptors, Dopamine
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Receptors, Dopamine D1
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Receptors, Dopamine D2
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Tetrahydronaphthalenes
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growth hormone, Lymnaea stagnalis
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Quinpirole
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Bucladesine
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2-(N,N-dipropyl)amino-6,7-dihydroxytetralin
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Sulpiride
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Cyclic AMP
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Dopamine