Opposing roles for D-1 and D-2 dopamine receptors in regulating the excitability of growth hormone-producing cells in the snail Lymnaea stagnalis

Eur J Pharmacol. 1984 Nov 13;106(2):431-5. doi: 10.1016/0014-2999(84)90735-0.

Abstract

Dopamine hyperpolarizes growth hormone-producing cells (GHC) in the CNS of Lymnaea stagnalis. This effect of dopamine was mimicked by the D-2 receptor agonist LY 141865 and antagonized by the D-2 receptor antagonists (-)-sulpiride and YM 09151-2. SKF 38393, a selective D-1 receptor agonist, increased the excitability of the GHC. This effect was mimicked by intracellular injection of cyclic AMP and antagonized by the D-1 receptor antagonist SCH 23390. Dopamine (in the presence of (-)-sulpiride) also increased the excitability of the GHC. It is concluded that both a D-1 and a D-2 receptor regulate the electrical activity of the GHC in the CNS of Lymnaea stagnalis.

MeSH terms

  • Animals
  • Bucladesine / pharmacology
  • Central Nervous System / metabolism
  • Cyclic AMP / pharmacology
  • Dopamine / pharmacology
  • Electrophysiology
  • Ergolines / pharmacology
  • Growth Substances / biosynthesis*
  • In Vitro Techniques
  • Invertebrate Hormones / biosynthesis*
  • Lymnaea / physiology*
  • Membrane Potentials / drug effects
  • Microelectrodes
  • Quinpirole
  • Receptors, Dopamine / physiology*
  • Receptors, Dopamine D1
  • Receptors, Dopamine D2
  • Sulpiride / pharmacology
  • Tetrahydronaphthalenes / pharmacology

Substances

  • Ergolines
  • Growth Substances
  • Invertebrate Hormones
  • Receptors, Dopamine
  • Receptors, Dopamine D1
  • Receptors, Dopamine D2
  • Tetrahydronaphthalenes
  • growth hormone, Lymnaea stagnalis
  • Quinpirole
  • Bucladesine
  • 2-(N,N-dipropyl)amino-6,7-dihydroxytetralin
  • Sulpiride
  • Cyclic AMP
  • Dopamine