Abstract
The reactivity of vesicular stomatitis virus (VSV) with kethoxal can be appreciably altered by treatment with 1-guanyl-3, 5-dimethyl pyrazole nitrate (GDMP) and proteolytic enzymes. Pretreatment of purified VSV with GDMP or proteolytic enzymes markedly reduced the effectiveness of kethoxal as a virucide. The rate of neutralizability of GDMP- and trypsin-treated viruses by specific antiserum differed from that of controls.
MeSH terms
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Aldehydes / pharmacology*
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Antiviral Agents / pharmacology*
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Butanones / pharmacology*
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Cell Line
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Guanidines / pharmacology*
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Hydrogen-Ion Concentration
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Indicators and Reagents
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Peptide Hydrolases / pharmacology*
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Pyrazoles / pharmacology*
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Trypsin / pharmacology
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Vesicular stomatitis Indiana virus / drug effects*
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Vesicular stomatitis Indiana virus / growth & development
Substances
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Aldehydes
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Antiviral Agents
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Butanones
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Guanidines
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Indicators and Reagents
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Pyrazoles
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Peptide Hydrolases
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Trypsin