[Methods for detecting "cataleptic states" in the rat]

Arzneimittelforschung. 1978;28(9):1504-5.
[Article in German]

Abstract

For the detection of drug-induced cataleptic states four new methods of "dynamic" character are described. They are based on passive extension of the muscles, changes in spatial position or force to motoric activity. Together with the well-known methods of "static" character, they are compiled to a "Test Battery" in which eight neuroleptics as well as bulbocapnine, metoclopramide, two cholinergic and two opioid drugs were investigated. Due to the pattern of reaction in the "Test Battery" it is possible to differentiate between various classes of cataleptiogenic drugs.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Behavior, Animal / drug effects
  • Catalepsy / chemically induced*
  • Catalepsy / physiopathology
  • Haloperidol / pharmacology
  • Humans
  • Methods
  • Oxotremorine / pharmacology
  • Rats

Substances

  • Oxotremorine
  • Haloperidol