Abstract
Baclofen and aminooxyacetic acid (AOAA) depressed the explorative and locomotor activity in rats. Baclofen, but not AOAA, decreased the locomotor stimulation, produced by apomorphine. Both compounds did not affect hyperactivity, induced by D, L-amphetamine, amantadine and methylphenidate. Neither baclofen nor AOAA influenced stereotypy induced by the above four substances.
MeSH terms
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Acetates / pharmacology*
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Amantadine / pharmacology
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Aminooxyacetic Acid / pharmacology*
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Amphetamines / pharmacology
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Animals
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Apomorphine / pharmacology
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Baclofen / pharmacology*
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Drug Interactions
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Humans
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Male
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Methylphenidate / pharmacology
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Motor Activity / drug effects
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Rats
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Receptors, Dopamine / drug effects*
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Stereotyped Behavior / drug effects
Substances
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Acetates
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Amphetamines
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Receptors, Dopamine
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Aminooxyacetic Acid
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Methylphenidate
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Amantadine
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Baclofen
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Apomorphine