Methotrexate analogues. 11. Unambiguous chemical synthesis and in vitro biological evaluation of alpha- and gamma-monoesters as potential prodrugs

J Med Chem. 1978 Apr;21(4):380-6. doi: 10.1021/jm00202a013.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Biotransformation
  • Cell Division / drug effects
  • Cells, Cultured
  • Esterases / blood
  • Esterification
  • Folic Acid Antagonists
  • Humans
  • In Vitro Techniques
  • Isomerism
  • Leukemia, Experimental / pathology
  • Methotrexate / analogs & derivatives*
  • Methotrexate / blood
  • Methotrexate / chemical synthesis
  • Methotrexate / pharmacology
  • Species Specificity

Substances

  • Folic Acid Antagonists
  • Esterases
  • Methotrexate