Objective measurement of performance during acute stress in patients with essential hypertension: assessment of the effects of propranolol and metoprolol

Clin Sci (Lond). 1979 Dec:57 Suppl 5:413s-415s. doi: 10.1042/cs057413s.

Abstract

1. A standardized method of objectively measuring performance during simulated car driving is described. 2. The effect of a single dose of propranolol and metoprolol were compared with placebo in two groups of patients with untreated essential hypertension. 3. Performance was similar after beta-adrenoreceptor-blocking agents or placebo. 4. Blood pressure response to stress persisted after administration of the blocking agents.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Automobile Driving
  • Blood Pressure / drug effects
  • Female
  • Heart Rate / drug effects
  • Humans
  • Hypertension / complications
  • Hypertension / physiopathology*
  • Male
  • Metoprolol*
  • Propanolamines*
  • Propranolol*
  • Stress, Psychological / complications
  • Stress, Psychological / physiopathology*

Substances

  • Propanolamines
  • Propranolol
  • Metoprolol