Abstract
The synthesis and the antitumor activities of a group of doxorubicin (adriamycin) 14-ethers are reported. The new compounds were found to have an activity similar to that of daunorubicin, at somewhat higher doses, but inferior to that of doxorubicin.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / therapeutic use
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Doxorubicin / chemical synthesis*
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Doxorubicin / therapeutic use
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Ethers / chemical synthesis
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Leukemia P388 / drug therapy*
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Leukemia, Experimental / drug therapy*
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Mice
Substances
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Antineoplastic Agents
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Ethers
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Doxorubicin