Effect of local anesthetics on intraocular penetration of subconjunctival antibiotics

Am J Ophthalmol. 1979 Aug;88(2):160-4. doi: 10.1016/0002-9394(79)90460-4.

Abstract

The combination of the subconjunctival injection of lidocaine HCl or procaine HCl with the subconjunctival injection of penicillin G, methicillin, cephaloridine, or gentamicin did not influence their intraocular penetration or subsequent antibiotic activity in aqueous humor of experimental animals.

MeSH terms

  • Anesthetics, Local / pharmacology*
  • Animals
  • Anti-Bacterial Agents / analysis*
  • Aqueous Humor / analysis*
  • Aqueous Humor / drug effects
  • Cephaloridine / analysis
  • Conjunctiva
  • Gentamicins / analysis
  • Injections
  • Lidocaine / pharmacology
  • Methicillin / analysis
  • Penicillin G / analysis
  • Procaine / pharmacology
  • Rabbits

Substances

  • Anesthetics, Local
  • Anti-Bacterial Agents
  • Gentamicins
  • Procaine
  • Lidocaine
  • Cephaloridine
  • Penicillin G
  • Methicillin