We have inquired into the variation of the secretion acid gastric in a man after a rapid infusion of an hipertonic solution of glucose (g 0,33/Kg of weight), comparing it with that induced by the caffeinic stimulant. From this comparison we have noticed a sharp secretory answer in the first 30' whether out of the HCl free or the total acidity that tends to become exhausted progressively. We want to put forward the hypothesis of a probable interference in a stimulating manner of the high glycemia over the production of entero-hormones.