Serum gammaglutamyl transpeptidase (gammaGT) and seudocholinesterase (CHE) were studied in 20 patients with acute viral hepatitis and 36 with alcoholic cirrhosis. All had from moderate to severe clinical evolution. gammaGT is an enzyme useful to determine, as to follow clinical-biochemical evolution of viral hepatitis specially in the colestatic form. CHE can be used as an evolution pointer of liver insufficiency specially in cirrhosis.