Synthesis and analgesic properties of N-phosphorylated derivatives of Phe-Ala and Phe-Gly

Int J Pept Protein Res. 1985 Aug;26(2):174-8. doi: 10.1111/j.1399-3011.1985.tb03194.x.

Abstract

N-Phosphoryl dipeptides derived from Phe-Ala, Phe-Ala-NH2 and Phe-Gly-NH2 were synthesized and their analgesic activity was evaluated in mice. Intracerebroventricular administration of P-Phe-Ala-NH2 produced a 100-fold increase in the analgesic potency of Phe-Ala and led to a potentiation and prolongation of the analgesic effect of the exogenously administered Met-enkephalin.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alanine
  • Analgesia
  • Analgesics / chemical synthesis*
  • Animals
  • Biological Assay
  • Dipeptides / chemical synthesis*
  • Dipeptides / therapeutic use
  • Glycine
  • Male
  • Mice
  • Mice, Inbred ICR
  • Phenylalanine
  • Phosphopeptides / chemical synthesis*
  • Phosphopeptides / therapeutic use
  • Structure-Activity Relationship

Substances

  • Analgesics
  • Dipeptides
  • Phosphopeptides
  • Phenylalanine
  • Alanine
  • Glycine