Abstract
N-Phosphoryl dipeptides derived from Phe-Ala, Phe-Ala-NH2 and Phe-Gly-NH2 were synthesized and their analgesic activity was evaluated in mice. Intracerebroventricular administration of P-Phe-Ala-NH2 produced a 100-fold increase in the analgesic potency of Phe-Ala and led to a potentiation and prolongation of the analgesic effect of the exogenously administered Met-enkephalin.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Alanine
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Analgesia
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Analgesics / chemical synthesis*
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Animals
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Biological Assay
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Dipeptides / chemical synthesis*
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Dipeptides / therapeutic use
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Glycine
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Male
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Mice
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Mice, Inbred ICR
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Phenylalanine
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Phosphopeptides / chemical synthesis*
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Phosphopeptides / therapeutic use
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Structure-Activity Relationship
Substances
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Analgesics
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Dipeptides
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Phosphopeptides
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Phenylalanine
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Alanine
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Glycine