[Study of macrophages infiltrating rat cardiac allografts. 1.--Description of the technique of heterotopic cardiac transplantation in the rat and morphological analysis of the cells infiltrating the graft (author's transl)]

M Lacombe; B Descamps; M N Feuillet; A M Camus; A T N'Guyen

[Study of macrophages infiltrating rat cardiac allografts. 1.--Description of the technique of heterotopic cardiac transplantation in the rat and morphological analysis of the cells infiltrating the graft (author's transl)]

Ann Biol Clin (Paris). 1979;37(5):271-4.

[Article in French]

Authors

M Lacombe, B Descamps, M N Feuillet, A M Camus, A T N'Guyen

PMID: 398162

Abstract

The technique of heterotopic cardiac transplantation in the rat is described in detail. A simple, nontraumatic method of obtaining cellular prints from the heart is proposed for the study of cells infiltrating the allograft. Analysis of the morphological aspect of the cellular infiltrate present at the time of rejection in a series of allografts revealed a very high proportion of cells belonging to the monocyte-macrophage series, thus suggesting an important role for these cells in the rejection process.

Publication types

English Abstract

MeSH terms

Animals
Ascitic Fluid / cytology
Graft Rejection*
Heart Transplantation*
Histocytochemistry
Lymphocytes / analysis
Macrophages / analysis*
Male
Monocytes / analysis
Myocardium / cytology*
Peritoneum
Plasma Cells / analysis
Rats
Transplantation, Homologous