Prognosis in Behcet's disease

Ann Ophthalmol. 1985 Jan;17(1):20-5.

Abstract

A retrospective clinical study made to determine the course and prognosis of the disease in 51 cases of Behçet's disease, with a follow-up of at least one year (average five years, range 1 to 15 years), showed that 45% of the eyes kept visual acuities of 1/10 or less, and 44% 8/10 or better, four years after the onset of the ocular symptoms. Ten years later, some 50% of the eyes had visual acuities of 1/10 or less and 32% had acuities of 8/10 or better. In the group of patients who were treated early with chlorambucil, the eye prognosis was significantly improved.

MeSH terms

  • Adolescent
  • Adult
  • Behcet Syndrome / diagnosis*
  • Behcet Syndrome / drug therapy
  • Behcet Syndrome / immunology
  • Behcet Syndrome / physiopathology
  • Central Nervous System Diseases / complications
  • Chlorambucil / adverse effects
  • Chlorambucil / therapeutic use
  • Eye Diseases / complications
  • Female
  • HLA Antigens / analysis
  • HLA-B Antigens*
  • HLA-B51 Antigen
  • Humans
  • Male
  • Middle Aged
  • Prognosis
  • Skin Diseases / complications
  • Steroids / therapeutic use
  • Stomatitis, Aphthous / complications
  • Vascular Diseases / complications
  • Visual Acuity / drug effects

Substances

  • HLA Antigens
  • HLA-B Antigens
  • HLA-B5 antigen
  • HLA-B51 Antigen
  • Steroids
  • Chlorambucil