[Pharmacologic activity of tert-aminoalkyl derivates of quinoxalinone, aza- and diaza-quinoxalinone]

Farmaco Sci. 1986 Jan;41(1):54-8.
[Article in Italian]

Abstract

Eight tert-aminoalkyl derivatives of 3-methyl-6R-quinoxalin-2-one, 3-methyl-6/8-azaquinoxalin-2-ones and 3-methyl-6,8-diazaquinoxalin-2-one, previously selected for their deconditioning activity in rats were now tested in mice for analgesic, explorative and incoordinating (muscle relaxant) activities; acute toxicity was also determined. Several compounds show a good degree of activity in the tests used.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amines / chemical synthesis
  • Amines / pharmacology
  • Amines / toxicity
  • Analgesics / chemical synthesis
  • Animals
  • Chemical Phenomena
  • Chemistry
  • Exploratory Behavior / drug effects
  • Female
  • Lethal Dose 50
  • Mice
  • Motor Activity / drug effects
  • Muscle Relaxants, Central / chemical synthesis*
  • Quinoxalines / chemical synthesis*
  • Quinoxalines / pharmacology
  • Quinoxalines / toxicity

Substances

  • Amines
  • Analgesics
  • Muscle Relaxants, Central
  • Quinoxalines