Reaction of cimetidine with Fenton reagent. A biomimetic model for the mixed-function oxidase drug metabolism

Eur J Biochem. 1986 Feb 3;154(3):603-5. doi: 10.1111/j.1432-1033.1986.tb09441.x.

Abstract

Cimetidine sulfoxide, N-desmethylcimetidine, N-desmethylcimetidine sulfoxide, cimetidine guanylurea, and the 5-hydroxymethylimidazole derivative of cimetidine sulfoxide were isolated from the reaction of cimetidine with Fenton reagent. The product distribution from the reaction of cimetidine with Fenton reagent clearly simulates the metabolism of cimetidine by the mixed-function oxidase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cimetidine*
  • Hydrogen Peroxide*
  • Iron*
  • Magnetic Resonance Spectroscopy
  • Mixed Function Oxygenases / metabolism*
  • Models, Chemical

Substances

  • Fenton's reagent
  • Cimetidine
  • Hydrogen Peroxide
  • Iron
  • Mixed Function Oxygenases