[Synthetic tripeptide miniluliberin and its biological activity]

V N Babichev; E I Adamskaia; N G Bukiia; Iu P Shvachkin; Iu N Tikhonov

[Synthetic tripeptide miniluliberin and its biological activity]

Probl Endokrinol (Mosk). 1985 Mar-Apr;31(2):47-9.

[Article in Russian]

Authors

V N Babichev, E I Adamskaia, N G Bukiia, Iu P Shvachkin, Iu N Tikhonov

PMID: 3921955

Abstract

The effects of the synthetic decapeptide LH-RH and tripeptide mini LH-RH on LH and FSH secretion were compared. Experiments on ovariectomized female rats receiving estradiol benzoate and progesterone showed that i. v. administration of mini LH-RH produced a stimulating effect on the release of gonadotrophins from the hypophysis. The effects of mini LH-RH were incomparable to those of LH-RH.

Publication types

Comparative Study

MeSH terms

Animals
Castration
Female
Follicle Stimulating Hormone / blood
Follicle Stimulating Hormone / metabolism
Gonadotropin-Releasing Hormone / analogs & derivatives*
Gonadotropin-Releasing Hormone / pharmacology
Luteinizing Hormone / blood
Luteinizing Hormone / metabolism
Rats
Time Factors

Substances

Gonadotropin-Releasing Hormone
Luteinizing Hormone
Follicle Stimulating Hormone