This study investigated perceived life satisfaction and quality of life reported by heart transplant recipients. The impact of life change following transplantation and problems associated with side-effects of the immunosuppressive therapy were also examined. Questionnaires were mailed to one hundred heart transplant recipients. All had survived at least six months after the operation. Seventy-five completed the questionnaire. Eighty-nine percent of those reported good to excellent quality of life. Life satisfaction was reported as good to very satisfactory by 82%. The considerable change in life style following transplantation was mostly perceived as positive. All recipients experienced some side-effects from the immunosuppressive therapy. However, these physical symptoms had little impact upon the overall positive evaluation of life quality and life satisfaction.