Chemotherapy plus immunotherapy for patients with primary and metastatic brain tumors

J Neurosurg Sci. 1985 Jan-Mar;29(1):19-24.

Abstract

The authors report two clinical trials concerning chemotherapy and immunotherapy combined in the treatment of primary and metastatic brain tumors. In the first study bacillus Calmette-Guerin (BCG) and in the second Levamisole (LMS) were utilized as immunostimulating agents. Chemotherapy was performed with BCNU or CCNU in association with surgery and/or radiotherapy. The immunological response was obtained but immunotherapy failed to demonstrate any significant effect on survival.

Publication types

  • Clinical Trial
  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Astrocytoma / therapy
  • BCG Vaccine / therapeutic use*
  • Brain Neoplasms / secondary
  • Brain Neoplasms / therapy*
  • Breast Neoplasms / therapy
  • Carmustine / therapeutic use*
  • Clinical Trials as Topic
  • Combined Modality Therapy
  • Female
  • Glioma / therapy
  • Humans
  • Levamisole / therapeutic use*
  • Lomustine / therapeutic use*
  • Lung Neoplasms / therapy
  • Male
  • Middle Aged
  • Prognosis

Substances

  • BCG Vaccine
  • Levamisole
  • Lomustine
  • Carmustine