Antimutagenic activity of the novel antileukemic agents, avarone and avarol

Mutat Res. 1985 Oct;144(2):63-6. doi: 10.1016/0165-7992(85)90002-8.

Abstract

The two antileukemic agents, avarone and avarol, were determined to be neither direct nor indirect mutagenic agents in the Ames microsomal test. Moreover, the two sesquiterpenoid compounds drastically reduced the mutagenic effect of benzo[a]pyrene in the same system. Subsequent enzymic studies demonstrated that avarone and avarol are powerful inhibitors of benzo[a]pyrene monooxygenase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology*
  • Benzopyrene Hydroxylase / antagonists & inhibitors
  • Biotransformation / drug effects
  • Carps
  • Cyclohexenes
  • Microsomes, Liver / drug effects
  • Microsomes, Liver / enzymology
  • Mutagenicity Tests
  • Mutagens / antagonists & inhibitors
  • Mutagens / metabolism
  • Salmonella typhimurium / drug effects
  • Sesquiterpenes / pharmacology*

Substances

  • Antineoplastic Agents
  • Cyclohexenes
  • Mutagens
  • Sesquiterpenes
  • avarone
  • Benzopyrene Hydroxylase
  • avarol