Thymoma with immunodeficiency (Good's syndrome) associated with myasthenia gravis and benign IgG gammopathy

Arch Intern Med. 1985 Sep;145(9):1704-7.

Abstract

We treated a case of thymoma with immunodeficiency (Good's syndrome) associated with a rare combination of other parathymic syndromes including myasthenia gravis, benign IgG lambda M component, pernicious anemia, and diabetes. The characterization of the patient's immunologic capacity disclosed practically normal T-cell number and mitogenic responses but impaired lymphokine production as well as B-cell function.

Publication types

  • Case Reports

MeSH terms

  • Humans
  • Hypergammaglobulinemia / complications*
  • Hypergammaglobulinemia / immunology
  • Immunoglobulin G / analysis*
  • Immunologic Deficiency Syndromes / complications*
  • Immunologic Deficiency Syndromes / immunology
  • Leukocyte Count
  • Leukocyte Migration-Inhibitory Factors / biosynthesis
  • Lymphocyte Activation
  • Male
  • Middle Aged
  • Myasthenia Gravis / complications*
  • Myasthenia Gravis / immunology
  • Syndrome
  • Thymectomy
  • Thymoma / complications*
  • Thymoma / immunology
  • Thymus Neoplasms / complications*
  • Thymus Neoplasms / immunology

Substances

  • Immunoglobulin G
  • Leukocyte Migration-Inhibitory Factors