Cerebral blood flow autoregulation and hypertension

Am J Med Sci. 1985 Jan;289(1):37-44. doi: 10.1097/00000441-198501000-00007.

Abstract

Hypertension and antihypertensive therapy have clinically important effects on cerebral blood flow. The autoregulatory changes that occur with chronic arterial hypertension should influence the clinician's choice of antihypertensive agents and the rapidity with which the blood pressure is lowered in order to avoid symptoms of focal or global cerebral hypoperfusion.

Publication types

  • Review

MeSH terms

  • Aged
  • Animals
  • Antihypertensive Agents / pharmacology
  • Brain Diseases / physiopathology*
  • Cerebrovascular Circulation* / drug effects
  • Chronic Disease
  • Homeostasis* / drug effects
  • Humans
  • Hypertension / physiopathology*
  • Hypertension, Malignant / etiology
  • Hypertension, Malignant / physiopathology
  • Intracranial Pressure / drug effects
  • Nifedipine / pharmacology
  • Nitroprusside / pharmacology
  • Papio
  • Rats
  • Rats, Inbred SHR

Substances

  • Antihypertensive Agents
  • Nitroprusside
  • Nifedipine