Use of an emulsion formulation of propofol ('Diprivan') in intravenous anaesthesia for termination of pregnancy. A comparison with methohexitone

Postgrad Med J. 1985:61 Suppl 3:129-31.

Abstract

The use of an emulsion formulation of 2,6-diisopropylphenol (propofol) for induction and maintenance of anaesthesia was compared with methohexitone in 60 patients undergoing termination of pregnancy. In the dosages chosen the two agents appeared to be equi-potent. Propofol was associated with a statistically significant superior quality of anaesthesia. Apnoea of greater than 30 s occurred in 8 patients who received propofol but in none of the patients who received methohexitone. Methohexitone was associated with coughing and laryngospasm in 5 patients. There was no difference in the recovery times between the 2 groups but the patients who received methohexitone were significantly more drowsy post-operatively.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial

MeSH terms

  • Abortion, Induced*
  • Adult
  • Anesthesia Recovery Period
  • Anesthesia, Intravenous*
  • Emulsions
  • Female
  • Humans
  • Methohexital* / adverse effects
  • Phenols* / administration & dosage
  • Phenols* / adverse effects
  • Pregnancy
  • Propofol
  • Time Factors

Substances

  • Emulsions
  • Phenols
  • Methohexital
  • Propofol