Disseminated mycobacterium avium complex spinal osteomyelitis in a patient with interferon gamma receptor deficiency: A case report

Sarah Jaggernauth; Andrew Waack; Alastair Hoyt; Jason Schroeder

doi:10.1016/j.radcr.2024.04.028

Disseminated mycobacterium avium complex spinal osteomyelitis in a patient with interferon gamma receptor deficiency: A case report

Radiol Case Rep. 2024 May 10;19(8):3070-3075. doi: 10.1016/j.radcr.2024.04.028. eCollection 2024 Aug.

Authors

Sarah Jaggernauth¹, Andrew Waack¹, Alastair Hoyt², Jason Schroeder²

Affiliations

¹ University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.
² ProMedica Physicians Neurosurgery, Toledo, OH 43606, USA.

Abstract

Disseminated mycobacterium avium complex (MAC) infection is rare and is classically associated with immunodeficient states. Osteomyelitis is a rare manifestation of disseminated MAC infection. The overwhelming majority of MAC infections occur in patients with human immunodeficiency virus (HIV). Disseminated MAC infection has been described in interferon gamma receptor deficiency, an immunodeficiency mechanistically linked to mycobacterial infection. We present a case of disseminated MAC vertebral osteomyelitis in a patient with interferon gamma receptor deficiency.

Keywords: Interferon gamma receptor deficiency; Mycobacterium avium complex; Osteomyelitis.

Publication types

Case Reports