A nanozyme multifunctional platform based on iron doped carbon dots derived from Tibetan Ganoderma lucidum waste for glucose sensing, anti-counterfeiting applications, and anticancer cell effect

Linjie Wang; Shujun Zheng; Yan Liu; Yang Ji; Xiaoya Liu; Fei Wang; Caolong Li

doi:10.1016/j.talanta.2024.126262

A nanozyme multifunctional platform based on iron doped carbon dots derived from Tibetan Ganoderma lucidum waste for glucose sensing, anti-counterfeiting applications, and anticancer cell effect

Talanta. 2024 May 15:276:126262. doi: 10.1016/j.talanta.2024.126262. Online ahead of print.

Authors

Linjie Wang¹, Shujun Zheng¹, Yan Liu¹, Yang Ji¹, Xiaoya Liu¹, Fei Wang², Caolong Li³

Affiliations

¹ Department of Chemistry, School of Science, China Pharmaceutical University, Nanjing 211198, Jiangsu, PR China.
² Department of Chemistry, School of Science, China Pharmaceutical University, Nanjing 211198, Jiangsu, PR China; Cell and Biomolecule Recognition Research Center, School of Science, China Pharmaceutical University, Nanjing, 211198, Jiangsu, PR China. Electronic address: feiwang@cpu.edu.cn.
³ Department of Chemistry, School of Science, China Pharmaceutical University, Nanjing 211198, Jiangsu, PR China; Cell and Biomolecule Recognition Research Center, School of Science, China Pharmaceutical University, Nanjing, 211198, Jiangsu, PR China. Electronic address: licl@cpu.edu.cn.

PMID: 38761660
DOI: 10.1016/j.talanta.2024.126262

Abstract

Implementing the concept of turning waste into treasure, the conversion of biomass waste into high-value carbon materials, especially carbon dots (CDs), has pointed out a new direction for disease diagnosis, tumor treatment, and other aspects. In this work, we have reported the GL-CDs(Fe) via a simple synthesis route exploiting Ganoderma lucidum waste as the precursor. Thanks to their excellent optical property and peroxidase mimetic activity, a novel GL-CDs(Fe)-based ratio fluorescence/colorimetric/smartphone triple mode sensing platform is cleverly fabricated for glucose determination with the LOD of 0.28, 0.37, and 0.52 μΜ separately. Especially, this triple mode biosensor is successfully utilized for glucose detection in serum samples with the relative error of less than ±8 % compared with clinical reports. Surprisingly, the GL-CDs(Fe) also presents immense application prospects in high-level anti-counterfeiting aspects due to their excellent luminescent properties, high water-solubility, and easy availability. Furthermore, GL-CDs(Fe) can catalyze excessive H₂O₂ inside tumor cells to produce massive hydroxyl radicals (·OH) which break down the redox levels of cancer cells and thereby eliminate tumor cells. Thus, this integrated "Three-in-One" multifunctional platform based on GL-CDs(Fe) unveils enormous research and application prospects for bio-sensing, anti-counterfeiting, cancer treatment.

Keywords: Eliminate tumor cells; Ganoderma lucidum waste; High-level anti-counterfeiting; Triple mode sensing platform; “Three-in-One” multifunctional platform.