The first diagnosis of Severe Fever with Thrombocytopenia Syndrome caused by tick-borne Severe Fever with Thrombocytopenia Syndrome virus in Chongqing, China: A case report and literature review

Xiefei Hu; Wenyan Wu; Shenshen Zhi; Wenjuan Xu; Yuanyuan Zhang; Lijuan Li; Yang Tao; Gang Duan; Chunyan Liao; Ling Wang; Lingyi Li; Zhifeng Li; Wei Li

doi:10.1016/j.diagmicrobio.2024.116350

The first diagnosis of Severe Fever with Thrombocytopenia Syndrome caused by tick-borne Severe Fever with Thrombocytopenia Syndrome virus in Chongqing, China: A case report and literature review

Diagn Microbiol Infect Dis. 2024 May 10;109(4):116350. doi: 10.1016/j.diagmicrobio.2024.116350. Online ahead of print.

Authors

Xiefei Hu¹, Wenyan Wu², Shenshen Zhi², Wenjuan Xu², Yuanyuan Zhang², Lijuan Li², Yang Tao³, Gang Duan⁴, Chunyan Liao⁴, Ling Wang⁴, Lingyi Li⁵, Zhifeng Li⁴, Wei Li⁶

Affiliations

¹ Medicine School of Chongqing University, Chongqing, China; Department of Clinical Laboratory, Chongqing Emergency Medical Center, School of Medicine, Chongqing University Central Hospital, Chongqing University, Chongqing 404100, China.
² Department of Clinical Laboratory, Chongqing Emergency Medical Center, School of Medicine, Chongqing University Central Hospital, Chongqing University, Chongqing 404100, China.
³ Intensive Care Unit, Chongqing Emergency Medical Center, School of Medicine, Chongqing University Central Hospital, Chongqing University, Chongqing, China.
⁴ Chongqing Municipal Center for Disease Control and Prevention, Microbiological Testing Institute, Chongqing 400042, China.
⁵ Department of Medical, Hangzhou Matridx Biotechnology Co., Ltd., No.2073 Jinchang road, Yuhang District, Hangzhou, Zhejiang, China.
⁶ Department of Clinical Laboratory, Chongqing Emergency Medical Center, School of Medicine, Chongqing University Central Hospital, Chongqing University, Chongqing 404100, China. Electronic address: 202137021029@stu.cqu.edu.cn.

PMID: 38761614
DOI: 10.1016/j.diagmicrobio.2024.116350

Abstract

Background: Severe Fever with Thrombocytopenia Syndrome (SFTS) is a tick-borne disease caused by the SFTS virus (SFTSV) which has the potential to become a pandemic and is currently a major public health concern.

Case presentation: We present the case of a 74-year-old female from an urban area of Chongqing, with leukocytopenia, thrombocytopenia, organ function, inflammatory, blood coagulation, and immune abnormalities. SFTSV infection was confirmed through molecular detection and metagenomic next-generation sequencing (mNGS) analysis, indicating a diagnosis of SFTS due to the patient's history of tick bites. The patient received symptomatic and supportive therapy, including antibiotics, antiviral treatment, and antifungal therapy, and finally discharged from the hospital on day 18.

Conclusions: This study highlights the need for increased awareness, early diagnosis, and prompt treatment for tick-borne SFTS. It also provides a comprehensive understanding of the disease's characteristics, pathogenesis, detection methods, and available treatments.

Keywords: Bunyavirales; Infection; Metagenomic next-generation sequencing; Severe Fever with Thrombocytopenia Syndrome; Treatment.

Publication types

Case Reports