Gastrointestinal Cancer Precursor Conditions and Their Detection

Asaf Maoz; Nicolette J Rodriguez; Matthew B Yurgelun; Sapna Syngal

doi:10.1016/j.hoc.2024.04.002

Gastrointestinal Cancer Precursor Conditions and Their Detection

Hematol Oncol Clin North Am. 2024 May 16:S0889-8588(24)00044-3. doi: 10.1016/j.hoc.2024.04.002. Online ahead of print.

Authors

Asaf Maoz¹, Nicolette J Rodriguez², Matthew B Yurgelun³, Sapna Syngal⁴

Affiliations

¹ Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA; Harvard Medical School, Boston, MA, USA. Electronic address: https://twitter.com/asaf_maoz.
² Harvard Medical School, Boston, MA, USA; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, 75 Francis Street, Boston MA 02115, USA; Division of Cancer Genetics and Prevention, 450 Brookline Avenue, Boston MA 02215, USA. Electronic address: https://twitter.com/Dr_NJRodriguez.
³ Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA; Harvard Medical School, Boston, MA, USA. Electronic address: https://twitter.com/MattYurgelun.
⁴ Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA. Electronic address: sapna_syngal@dfci.harvard.edu.

PMID: 38760197
DOI: 10.1016/j.hoc.2024.04.002

Abstract

Gastrointestinal cancers are a leading cause of cancer morbidity and mortality. Many gastrointestinal cancers develop from cancer precursor lesions, which are commonly found in individuals with hereditary cancer syndromes. Hereditary cancer syndromes have advanced our understanding of cancer development and progression and have facilitated the evaluation of cancer prevention and interception efforts. Common gastrointestinal hereditary cancer syndromes, including their organ-specific cancer risk and surveillance recommendations, are reviewed in this article. The management of common gastroesophageal, pancreatic, and colonic precursor lesions is also discussed, regardless of their genetic background. Further research is needed to advance chemoprevention and immunoprevention strategies.

Keywords: CDH1; Cancer detection; Cancer prevention; Hereditary pancreatic cancer; Lynch syndrome; Polyposis.

Publication types

Review