Palliative treatment of generalized metastatic follicular carcinoma of thyroid after operation: A case report and literature review

Medicine (Baltimore). 2024 May 17;103(20):e38237. doi: 10.1097/MD.0000000000038237.

Abstract

Rationale: Follicular carcinoma of thyroid is a rare pathological type of thyroid carcinoma, accounting for 4.5% of the total. At present, the main treatment methods include surgery, iodine therapy, thyroid hormone inhibitors, etc. Targeted drug therapy is very important for distant metastasis and iodine-refractory differentiated thyroid cancer.

Patient concerns: This clinical case is a 51-year-old male patient with follicular carcinoma of thyroid.

Diagnoses: After 7 years of total thyroidectomy, multiple distant metastasis occurred to bilateral lungs, bones, multiple lymph nodes, etc.

Intervention: After multidisciplinary consultation in the department of oncology, thoracic surgery, nuclear medicine and other departments, he received targeted drug therapy of Lenvatinib.

Outcomes: After 3 months, his condition was partially relieved, and his quality of life was significantly improved. After 11 months of treatment, the evaluated efficacy was still in remission.

Lesson: Late metastatic thyroid cancer is faced with dilemma of radioiodine refractory after traditional treatment. This will provide further evidence for therapeutic intervention in similar patients in the future.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adenocarcinoma, Follicular* / pathology
  • Adenocarcinoma, Follicular* / secondary
  • Adenocarcinoma, Follicular* / surgery
  • Adenocarcinoma, Follicular* / therapy
  • Antineoplastic Agents / therapeutic use
  • Humans
  • Male
  • Middle Aged
  • Palliative Care* / methods
  • Phenylurea Compounds / therapeutic use
  • Quinolines / therapeutic use
  • Thyroid Neoplasms* / pathology
  • Thyroid Neoplasms* / therapy
  • Thyroidectomy* / methods

Substances

  • lenvatinib