Therapeutic Promises of Ferulic Acid and Its Derivatives on Hepatic damage Related with Oxidative Stress and Inflammation: A Review with Mechanisms

Md Shimul Bhuia; Raihan Chowdhury; Manik Shill; Afsana Chowdhury; Henrique Coutinho; Davi Silva; Antonio Raposo; Muhammad Torequl Islam

doi:10.1002/cbdv.202400443

Therapeutic Promises of Ferulic Acid and Its Derivatives on Hepatic damage Related with Oxidative Stress and Inflammation: A Review with Mechanisms

Chem Biodivers. 2024 May 17:e202400443. doi: 10.1002/cbdv.202400443. Online ahead of print.

Authors

Md Shimul Bhuia¹, Raihan Chowdhury¹, Manik Shill², Afsana Chowdhury¹, Henrique Coutinho³, Davi Silva⁴, Antonio Raposo⁵, Muhammad Torequl Islam¹

Affiliations

¹ Bangabandhu Sheikh Mujib Medical University, PHARMACY, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, BANGLADESH.
² Bangabandhu Sheikh Mujibur Rahman Agricultural University, PHARMACY, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, BANGLADESH.
³ URCA, DQB, Av. Cel Antonio Luiz, 1161. Pimenta, Not Available, 63105-000, Crato, BRAZIL.
⁴ Paraiba Federal University, pathology, UFPB, joão pessoa, BRAZIL.
⁵ Lusofona University, BIOTECHNOLOGY, Lusofona University of Humanities and Technologies Faculty of Law, LISBOA, PORTUGAL.

PMID: 38757848
DOI: 10.1002/cbdv.202400443

Abstract

Ferulic acid (FA) is a naturally occurring phenolic compound commonly found in the plant Ferula communis. This study aims to investigate the hepatoprotective effect of FA and its derivatives (methyl ferulic acid and trans-ferulic acid) against oxidative stress and inflammation-related hepatotoxicity due to toxicants based on the results of different non-clinical and preclinical tests. For this, data was collected from different reliable electronic databases such as PubMed, Google Scholar, and ScienceDirect, etc. The results of this investigation demonstrated that FA and its derivatives have potent hepatoprotective effects against oxidative stress and inflammation-related damage. The findings also revealed that these protective effects are due to the antioxidant and anti-inflammatory effects of the chemical compound. FA and its analogues significantly inhibit free radical generation and hinder the effects of proinflammatory markers and inflammatory enzymes, resulting in diminished cytotoxic and apoptotic hepatocyte death. The compounds also prevent intracellular lipid accumulation and provide protective effects.

Keywords: Antioxidant activity; Ferulic acid; Hepatoprotective effect; Methyl ferulic acid.