Introduction: This study aimed to evaluate the anti-cancer effects of gedunin, a natural compound, in a rat model of gastric carcinogenesis induced by MNNG.
Methods: Fifty-four rats were randomly assigned to six groups for a 60-day study on the effects of MNNG and gedunin. Groups 1-4 received 200 mg/kg MNNG (1, 10, or 100 mg/kg), and group 5 had only 100 mg/kg gedunin.
Results: Gedunin at low doses exhibited anti-cancer and protective properties against MNNG-induced damage, including reduced inflammation, and apoptosis.
Conclusions: Gedunin demonstrates a U-shaped dose-response, with low doses offering protection and high doses promoting tumor growth.
Keywords: HMGB1/PI3K/AKT pathway; apoptosis; gastric cancer; gedunin; inflammation.
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