Bladder cancer (BC) is one of the 3 common malignant tumors in the urinary system, with high incidence, easy metastasis, poor therapeutic efficacy, and poor prognosis, which seriously threatens the health of human. Tumor cells exhibit a strong demand for iron, and iron overload can induce ferroptosis, which is an iron dependent cell death caused by lipid peroxidation and cell membrane damage. Therefore, ferroptosis has strong anti-tumor potential. The molecular mechanisms of ferroptosis is associated with abnormalities in cellular phospholipid metabolism and iron metabolism, and dysregulation of antioxidant and non-antioxidant systems Xc-/glutathione (GSH)/glutathione peroxidase 4 (GPX4). Ferroptosis relevant molecules play important roles in the occurrence and development, metastasis, drug resistance, and immune response of BC, and are expected to become targets for the treatment of BC.
膀胱癌(bladder cancer，BC)是泌尿系统三大常见恶性肿瘤之一，具有发病率高、易转移、治疗效果不佳、预后较差的特点，严重威胁着全人类的健康。肿瘤细胞表现出强烈的需铁现象，而铁超载会诱导细胞发生铁死亡，即一种由脂质过氧化和细胞膜损伤引起的铁依赖性细胞死亡。因此，铁死亡具有很强的抗肿瘤潜力。铁死亡的分子机制与细胞磷脂代谢异常、铁代谢异常、抗氧化和非抗氧化系统Xc-/谷胱甘肽(glutathione，GSH)/谷胱甘肽过氧化物酶4(glutathione peroxidase 4，GPX4)的失调有关。铁死亡相关分子在BC的发生和发展、转移、耐药及免疫反应等方面发挥着重要的作用，有望成为治疗BC的靶点。.
Keywords: Xc-/glutathione/glutathione peroxidase 4; bladder cancer; ferroptosis; ferroptosis relevant molecules; iron metabolism; lipid peroxidation; phospholipid metabolism.