Disease burden and macrolide resistance of Mycoplasma pneumoniae infection in adults in Asia-Pacific region

Chih-Cheng Lai; Chun-Chung Hsueh; Chi-Kuei Hsu; Ya-Wen Tsai; Po-Ren Hsueh

doi:10.1016/j.ijantimicag.2024.107205

Disease burden and macrolide resistance of Mycoplasma pneumoniae infection in adults in Asia-Pacific region

Int J Antimicrob Agents. 2024 May 14:107205. doi: 10.1016/j.ijantimicag.2024.107205. Online ahead of print.

Authors

Chih-Cheng Lai¹, Chun-Chung Hsueh², Chi-Kuei Hsu³, Ya-Wen Tsai⁴, Po-Ren Hsueh⁵

Affiliations

¹ Division of Hospital Medicine, Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan; School of Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan.
² Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
³ Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan; School of Medicine for International Students, College of Medicine, I-Shou University, Kaohsiung, Taiwan.
⁴ Center for Integrative Medicine, Chi Mei Medical Center, Tainan, Taiwan.
⁵ Division of Infectious Diseases, Department of Internal Medicine, China Medical University Hospital, School of Medicine, China Medical University, Taichung, Taiwan; Department of Laboratory Medicine, China Medical University Hospital, School of Medicine, China Medical University, Taichung, Taiwan. Electronic address: hsporen@gmail.com.

PMID: 38754527
DOI: 10.1016/j.ijantimicag.2024.107205

Abstract

In the Asia-Pacific region, Mycoplasma pneumoniae (MP) could be a notable pathogen responsible for adult community-acquired pneumonia (CAP), with varying prevalence rates. This comprehensive review explores the epidemiology, clinical manifestations, macrolide resistance, and molecular characteristics of MP in adults across several countries in Asia. The prevalence of MP in CAP patients in these countries ranged from 2.1% in Korea to 25.5% in Japan. Macrolide resistance was prominent, particularly in China, with rates ranging from 26.9% to 100%. Clinical manifestations of MP infection included protean extra-pulmonary manifestations, and complications such as rhabdomyolysis and thrombocytopenia. Molecular characteristics, especially the multiple locus variable-number tandem-repeat analysis type 4/5/7/2, remained predominant across various countries, emphasizing the importance of ongoing surveillance. The review highlights the urgent need for continued monitoring of MP infections, macrolide resistance, and molecular characteristics to inform effective prevention and treatment strategies in the Asia-Pacific region.

Keywords: Asia-Pacific region; Community-acquired pneumonia; Macrolide resistance; Mycoplasma pneumoniae.

Publication types

Review