A Pediatric Case of Encephalopathy With Hypoglycemia Induced by Coxsackievirus A4 Infection

Masahiro Ishii; Takayuki Hoshina; Tsuguto Fujimoto; Nozomu Hanaoka; Masami Konagaya; Reiko Shimbashi; Sayaka Takanashi; Satoru Arai; Keiko Tanaka-Taya; Koichi Kusuhara

doi:10.1097/INF.0000000000004390

A Pediatric Case of Encephalopathy With Hypoglycemia Induced by Coxsackievirus A4 Infection

Pediatr Infect Dis J. 2024 May 10. doi: 10.1097/INF.0000000000004390. Online ahead of print.

Authors

Masahiro Ishii¹, Takayuki Hoshina¹, Tsuguto Fujimoto^{2

3

4}, Nozomu Hanaoka^{2

3}, Masami Konagaya^{2

5}, Reiko Shimbashi², Sayaka Takanashi², Satoru Arai², Keiko Tanaka-Taya^{2

6}, Koichi Kusuhara¹

Affiliations

¹ From the Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu.
² Center for Surveillance, Immunization, and Epidemiologic Research.
³ Center for Emergency Preparedness and Response.
⁴ Department of Fungal Infection, National Institute of Infectious Diseases, Tokyo.
⁵ Research Division, UMA Corporation, Chiba; and.
⁶ Kanagawa Prefectural Institute of Public Health, Kanagawa, Japan.

PMID: 38753991
DOI: 10.1097/INF.0000000000004390

Abstract

We report a pediatric case developing hypoglycemic encephalopathy during the acute phase of coxsackievirus (CV)-A4 infection. A part of the sequence of the virus detected from our patient was completely identical to that in other CV-A4 strain reported as a recombinant strain with lethal CV-A2, suggesting that the properties of CV-A4 might be associated with the severe hypoglycemic encephalopathy.