There is a large body of research exploring therapeutic effectiveness for racially or ethnically minoritized college students. Prior literature highlights the unique mental health and academic challenges faced by Native American students in higher education; however, there is a paucity of research examining the effectiveness of counseling for Native American college students. The present study examined the effectiveness of counseling on psychological and academic distress among Native American college students, comparing their initial distress and rate of change to White students in counseling. Using naturalistic data from a large practice-research network spanning 2015-2019, we employed hierarchical linear modeling to evaluate the effect of race on psychological distress (N = 9,621) and academic distress (N = 9,643) scores during treatment. Results revealed that all clients demonstrated a significant decrease in both types of distress over the course of treatment. Native American and White clients presented to counseling with similar levels of psychological distress. However, Native American clients experienced more change and at a faster rate on psychological distress symptoms compared to White clients. On academic distress, Native American clients began and concluded counseling with higher levels of distress while experiencing a similar amount of change at a similar rate in their reduction of academic distress over the course of treatment. The study findings provide unique insight on the outcomes of treatment-seeking Native students by demonstrating a significant positive response to counseling, as well as novel comparisons between Native and White students receiving services within college counseling settings. (PsycInfo Database Record (c) 2024 APA, all rights reserved).