HOXA9 versus HOXB9; particular focus on their controversial role in tumor pathogenesis

Ahmed Hjazi; Saade Abdalkareem Jasim; Aiman Mohammed Baqir Al-Dhalimy; Pooja Bansal; Harpreet Kaur; Maytham T Qasim; Israa Hussein Mohammed; Mahamedha Deorari; Mohammed Abed Jawad; Ahmed Hussein Zwamel

doi:10.1007/s13353-024-00868-x

HOXA9 versus HOXB9; particular focus on their controversial role in tumor pathogenesis

J Appl Genet. 2024 May 16. doi: 10.1007/s13353-024-00868-x. Online ahead of print.

Authors

Affiliations

¹ Department of Medical Laboratory, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, 11942, Al-Kharj, Saudi Arabia.
² Medical Laboratory Techniques Department, Al-Maarif University College, Anbar, Iraq. saade.a.j@uoa.edu.iq.
³ Department of Nursing, Altoosi University College, Najaf, Iraq.
⁴ Department of Biotechnology and Genetics, Jain (Deemed-to-Be) University, Bengaluru, Karnataka, 560069, India.
⁵ Department of Allied Healthcare and Sciences, Vivekananda Global University, Jaipur, Rajasthan, 303012, India.
⁶ School of Basic & Applied Sciences, Shobhit University, Gangoh, Uttar Pradesh, 247341, India.
⁷ Department of Health & Allied Sciences, Arka Jain University, Jamshedpur, Jharkhand, 831001, India.
⁸ College of Health and Medical Technology, Al-Ayen University, Thi-Qar, Nasiriyah, 64001, Iraq.
⁹ College of Nursing, National University of Science and Technology, Dhi Qar, Nasiriyah, Iraq.
¹⁰ Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India.
¹¹ Department of Medical Laboratories Technology, Al-Nisour University College, Baghdad, Iraq.
¹² Medical Laboratory Technique College, The Islamic University, Najaf, Iraq.
¹³ Medical Laboratory Technique College, The Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq.
¹⁴ Medical Laboratory Technique College, The Islamic University of Babylon, Babylon, Iraq.

PMID: 38753266
DOI: 10.1007/s13353-024-00868-x

Abstract

The Homeobox (HOX) gene family is essential to regulating cellular processes because it maintains the exact coordination required for tissue homeostasis, cellular differentiation, and embryonic development. The most distinctive feature of this class of genes is the presence of the highly conserved DNA region known as the homeobox, which is essential for controlling their regulatory activities. Important players in the intricate process of genetic regulation are the HOX genes. Many diseases, especially in the area of cancer, are linked to their aberrant functioning. Due to their distinctive functions in biomedical research-particularly in the complex process of tumor advancement-HOXA9 and HOXB9 have drawn particular attention. HOXA9 and HOXB9 are more significant than what is usually connected with HOX genes since they have roles in the intricate field of cancer and beyond embryonic processes. The framework for a focused study of the different effects of HOXA9 and HOXB9 in the context of tumor biology is established in this study.

Keywords: Cancer; HOX family; HOXA9; HOXB9.

Publication types

Review

Grants and funding

PSAU/2024/R/1445/Deanship of Scientific Research, Prince Sattam bin Abdulaziz University